A pyrophosphate-activated nanochannel inspired by a TRP ion channel

Fei Zhu; Guanxing Yang; Manivannan Kalavathi Dhinakaran; Rui Wang; Miaomiao Song; Haibing Li

doi:10.1039/C9CC06615B

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A pyrophosphate-activated nanochannel inspired by a TRP ion channel†

Fei Zhu,^a Guanxing Yang,^a Manivannan Kalavathi Dhinakaran,^a Rui Wang,^a Miaomiao Song^a and Haibing Li

*^a

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* Corresponding authors

^a Key Laboratory of Pesticide and Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China
E-mail: lhbing@mail.ccnu.edu.cn

Abstract

A pyrophosphate (PPi) selectively activated potassium channel was constructed via introducing the isoniazid functionalized calix[4]arene (C4NP) into a biomimetic nanochannel. The activation mechanism is mainly due to the changing of the inner surface charge and wettability of the nanochannel caused by PPi binding.

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Article information

DOI: https://doi.org/10.1039/C9CC06615B
Article type: Communication
Submitted: 25 Aug 2019
Accepted: 25 Sep 2019
First published: 02 Oct 2019

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Chem. Commun., 2019,55, 12833-12836

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A pyrophosphate-activated nanochannel inspired by a TRP ion channel

F. Zhu, G. Yang, M. K. Dhinakaran, R. Wang, M. Song and H. Li, Chem. Commun., 2019, 55, 12833 DOI: 10.1039/C9CC06615B

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Chemical Communications

A pyrophosphate-activated nanochannel inspired by a TRP ion channel†

Abstract

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A pyrophosphate-activated nanochannel inspired by a TRP ion channel

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