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Issue 96, 2019
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Macromolecular approach for targeted radioimmunotherapy in non-Hodgkin's lymphoma

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Abstract

Polymers are an attractive anchoring platform for the synthesis of radioimmunoconjugates. They enable independent control over the amount of radioisotope loading and antibody attachment, which is pivotal in developing tailorable formulations for personalised medicine. Herein, we report the synthesis of p(HEMA-ran-GMA) for the conjugation of lutetium ions and rituximab as a functional platform for radioimmunotherapy. We demonstrate the suitability of this platform using non-Hodgkin's lymphoma cells.

Graphical abstract: Macromolecular approach for targeted radioimmunotherapy in non-Hodgkin's lymphoma

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Supplementary files

Article information


Submitted
25 Aug 2019
Accepted
01 Nov 2019
First published
15 Nov 2019

Chem. Commun., 2019,55, 14506-14509
Article type
Communication

Macromolecular approach for targeted radioimmunotherapy in non-Hodgkin's lymphoma

C. Hee, D. Ho, A. Karton, G. Nealon, J. A. Kretzmann, M. Norret and K. S. Iyer, Chem. Commun., 2019, 55, 14506
DOI: 10.1039/C9CC06603A

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