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Issue 84, 2019
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Mitochondrial heat shock protein-guided photodynamic therapy

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Abstract

Mitochondria targeting sensitizers are continuing to gain importance in photodynamic therapy (PDT). Members of the 90 kDa heat shock protein (Hsp90) family, including TRAP1 (Hsp75), are overexpressed in cancer cells and help to control the antiapoptotic protein activity. The present work introduces an Hsp90 inhibitor-mitochondria targeting indocyanine dye conjugate (IR-PU) for high PDT efficacy.

Graphical abstract: Mitochondrial heat shock protein-guided photodynamic therapy

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Article information


Submitted
19 Aug 2019
Accepted
19 Sep 2019
First published
27 Sep 2019

Chem. Commun., 2019,55, 12631-12634
Article type
Communication

Mitochondrial heat shock protein-guided photodynamic therapy

A. P. Thomas, A. Lee, L. Palanikumar, B. Jana, K. Kim, S. Kim, H. Ok, J. Seol, D. Kim, B. H. Kang and J. Ryu, Chem. Commun., 2019, 55, 12631
DOI: 10.1039/C9CC06411G

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