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Bipedal DNA walker mediated enzyme-free exponential isothermal signal amplification for rapid detection of microRNA

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Abstract

In this work, a bipedal DNA walker was employed to mediate an efficient enzyme-free exponential isothermal DNA signal amplification. On the basis of the bipedal DNA walker mediated enzyme-free exponential isothermal signal amplification, an electrochemiluminescence (ECL) biosensor was constructed for sensitive and rapid detection of microRNA (miRNA) with a limit of detection down to 0.24 fM and requiring less than 40 min.

Graphical abstract: Bipedal DNA walker mediated enzyme-free exponential isothermal signal amplification for rapid detection of microRNA

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Publication details

The article was received on 11 Aug 2019, accepted on 21 Oct 2019 and first published on 21 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06214A
Chem. Commun., 2019, Advance Article

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    Bipedal DNA walker mediated enzyme-free exponential isothermal signal amplification for rapid detection of microRNA

    A. Chen, Y. Zhuo, Y. Chai and R. Yuan, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC06214A

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