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Issue 89, 2019
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A glucose-depleting silica nanosystem for increasing reactive oxygen species and scavenging glutathione in cancer therapy

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Abstract

Cancer cells adapt to cellular oxidative stress by increasing glutathione (GSH). An organically modified silica nanosystem (ORMOSIL@GOx) was fabricated to achieve a lethal level of oxidative stress in cancer cells by depleting intracellular GSH while increasing reactive oxygen species.

Graphical abstract: A glucose-depleting silica nanosystem for increasing reactive oxygen species and scavenging glutathione in cancer therapy

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Publication details

The article was received on 03 Aug 2019, accepted on 11 Oct 2019 and first published on 11 Oct 2019


Article type: Communication
DOI: 10.1039/C9CC06043J
Chem. Commun., 2019,55, 13374-13377

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    A glucose-depleting silica nanosystem for increasing reactive oxygen species and scavenging glutathione in cancer therapy

    W. K. Ong, D. Jana and Y. Zhao, Chem. Commun., 2019, 55, 13374
    DOI: 10.1039/C9CC06043J

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