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Chemical biology suggests pleiotropic effects for a novel hexanuclear copper(ii) complex inducing apoptosis in hepatocellular carcinoma cells

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Abstract

A novel hexanuclear copper(II)-based complex, [Cu6(tpbb)2(NO3)12] (1), was synthesized, which shows potent cytotoxicity to hepatoma carcinoma cells by inducing apoptosis and apoptosis-related processes. Furthermore, mechanistic investigations based on proteomes revealed that the induced apoptosis was mediated by acting on several targets and multiple pathways in a pleiotropic way.

Graphical abstract: Chemical biology suggests pleiotropic effects for a novel hexanuclear copper(ii) complex inducing apoptosis in hepatocellular carcinoma cells

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Publication details

The article was received on 01 Aug 2019, accepted on 10 Sep 2019 and first published on 11 Sep 2019


Article type: Communication
DOI: 10.1039/C9CC05995D
Chem. Commun., 2019, Advance Article

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    Chemical biology suggests pleiotropic effects for a novel hexanuclear copper(II) complex inducing apoptosis in hepatocellular carcinoma cells

    J. Zhang, J. Hu, K. Peng, W. Song, S. Zhi, E. Yang, J. Zhao and H. Hou, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC05995D

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