Issue 79, 2019
From the journal:

Chemical Communications

Chemical biology suggests pleiotropic effects for a novel hexanuclear copper(ii) complex inducing apoptosis in hepatocellular carcinoma cells†

Junshuai Zhang,a   Jiyong Hu,a   Kun Peng,b   Wei Song,a   Shuangcheng Zhi,a   Endian Yang,a   Jin’an Zhao ORCID logo *ac  and  Hongwei Hou ORCID logo c  

* Corresponding authors

a College of Material and Chemical Engineering, Henan University of Urban Construction, Henan 467036, P. R. China

b Institute of Inorganic Chemistry, University of Wuerzburg, Bavaria 97074, Germany

c College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001, China
E-mail: zjinan@zzu.edu.cn

Abstract

A novel hexanuclear copper(II)-based complex, [Cu6(tpbb)2(NO3)12] (1), was synthesized, which shows potent cytotoxicity to hepatoma carcinoma cells by inducing apoptosis and apoptosis-related processes. Furthermore, mechanistic investigations based on proteomes revealed that the induced apoptosis was mediated by acting on several targets and multiple pathways in a pleiotropic way.

Graphical abstract: Chemical biology suggests pleiotropic effects for a novel hexanuclear copper(ii) complex inducing apoptosis in hepatocellular carcinoma cells

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Article information

DOI
https://doi.org/10.1039/C9CC05995D
Article type
Communication
Submitted
01 Aug 2019
Accepted
10 Sep 2019
First published
11 Sep 2019

Chem. Commun., 2019,55, 11944-11947

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Chemical biology suggests pleiotropic effects for a novel hexanuclear copper(II) complex inducing apoptosis in hepatocellular carcinoma cells

J. Zhang, J. Hu, K. Peng, W. Song, S. Zhi, E. Yang, J. Zhao and H. Hou, Chem. Commun., 2019, 55, 11944 DOI: 10.1039/C9CC05995D

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