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Issue 79, 2019
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Primary amides to amines or nitriles: a dual role by a single catalyst

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Abstract

We report a manganese-catalyzed hydrosilylative reduction of various primary amides to amines (25 examples). On simple modification of the reaction conditions such as in the presence of a catalytic amount of secondary amide, the same catalyst can transform the primary amides into intermediate nitrile compounds (16 examples) in excellent yields. This is the first example where such a controlled catalytic transformation of primary amides to amines or nitriles with a single catalyst has been demonstrated.

Graphical abstract: Primary amides to amines or nitriles: a dual role by a single catalyst

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Article information


Submitted
27 Jul 2019
Accepted
04 Sep 2019
First published
04 Sep 2019

Chem. Commun., 2019,55, 11868-11871
Article type
Communication

Primary amides to amines or nitriles: a dual role by a single catalyst

H. S. Das, S. Das, K. Dey, B. Singh, R. K. Haridasan, A. Das, J. Ahmed and S. K. Mandal, Chem. Commun., 2019, 55, 11868
DOI: 10.1039/C9CC05856G

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