Water-mediated C–H activation of arenes with secure carbene precursors: the reaction and its application

Ruifang Nie; Ruizhi Lai; Songyang Lv; Yingying Xu; Li Guo; Qiantao Wang; Yong Wu

doi:10.1039/C9CC05804D

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Water-mediated C–H activation of arenes with secure carbene precursors: the reaction and its application†

Ruifang Nie,‡^a Ruizhi Lai,‡^a Songyang Lv,^a Yingying Xu,^a Li Guo,^a Qiantao Wang*^a and Yong Wu

*^a

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* Corresponding authors

^a Sichuan Engineering Laboratory for Plant-Sourced Drug and Research Center for Drug Industrial Technology, Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, China
E-mail: qwang@scu.edu.cn, wyong@scu.edu.cn

Abstract

A water-mediated C–H activation using sulfoxonium ylides is reported, providing a general, green and step-economic approach to construct a C–C bond and varieties of useful N-heterocycle scaffolds. Notably, the “water-mediated” activation, in contrast to that in organic solvents, shows great potential in pharmaceutical, biochemistry and chemical industries.

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Article information

DOI: https://doi.org/10.1039/C9CC05804D
Article type: Communication
Submitted: 26 Jul 2019
Accepted: 27 Aug 2019
First published: 27 Aug 2019

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Chem. Commun., 2019,55, 11418-11421

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Water-mediated C–H activation of arenes with secure carbene precursors: the reaction and its application

R. Nie, R. Lai, S. Lv, Y. Xu, L. Guo, Q. Wang and Y. Wu, Chem. Commun., 2019, 55, 11418 DOI: 10.1039/C9CC05804D

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Chemical Communications

Water-mediated C–H activation of arenes with secure carbene precursors: the reaction and its application†

Abstract

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Water-mediated C–H activation of arenes with secure carbene precursors: the reaction and its application

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