Issue 83, 2019
From the journal:

Chemical Communications

Neutralization of insulin by photocleavage under high vacuum†

Jonas Schätti,a   Moritz Kriegleder,b   Maxime Debiossac, ORCID logo b   Michael Kerschbaum,b   Philipp Geyer,b   Marcel Mayor, ORCID logo acd   Markus Arndt ORCID logo *b  and  Valentin Köhler ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Basel, St. Johannsring 19, CH Basel, Switzerland
E-mail: valentin.koehler@unibas.ch

b Faculty of Physics, University of Vienna, Boltzmanngasse 5, A-1090 Vienna, Austria
E-mail: markus.arndt@univie.ac.at

c Institute of Nanotechnology, Karlsruhe Institute of Technology, Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany

d Lehn Institute of Functional Materials (LIFM), Sun Yat-Sen University (SYSU), XinGangXi Road 135, 510275 Guangzhou, P. R. China

Abstract

Charge reduction and neutralization of electro-sprayed peptides are realized by selective gas-phase photocleavage of tailored covalent tags. The concept is demonstrated with four model peptides in positive and negative ion modes and tagged insulin as the largest construct.

Graphical abstract: Neutralization of insulin by photocleavage under high vacuum

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Article information

DOI
https://doi.org/10.1039/C9CC05712A
Article type
Communication
Submitted
23 Jul 2019
Accepted
25 Sep 2019
First published
25 Sep 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2019,55, 12507-12510

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Neutralization of insulin by photocleavage under high vacuum

J. Schätti, M. Kriegleder, M. Debiossac, M. Kerschbaum, P. Geyer, M. Mayor, M. Arndt and V. Köhler, Chem. Commun., 2019, 55, 12507 DOI: 10.1039/C9CC05712A

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