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Expanding the biological utility of bis-NHC gold(I) complexes through post synthetic carbamate conjugation

Abstract

We report the synthesis of a novel hydroxyl-functionalised heteroleptic bis-NHC gold(I) complex that permits conjugation to various amines via carbamate bond formation. The resulting derivatives were studied in vitro using cell proliferation assays and fluorescent microscopic imaging of human cancer cell lines.

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Publication details

The article was received on 21 Jul 2019, accepted on 13 Aug 2019 and first published on 14 Aug 2019


Article type: Communication
DOI: 10.1039/C9CC05635A
Chem. Commun., 2019, Accepted Manuscript

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    Expanding the biological utility of bis-NHC gold(I) complexes through post synthetic carbamate conjugation

    S. Sen, Y. Li, V. Lynch, K. Arumugam, J. L. Sessler and J. Arambula, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC05635A

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