Expanding the biological utility of bis-NHC gold(I) complexes through post synthetic carbamate conjugation

Sajal Sen; Yue Li; Vincent Lynch; Kuppuswamy Arumugam; Jonathan L. Sessler; Jonathan F. Arambula

doi:10.1039/C9CC05635A

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Expanding the biological utility of bis-NHC gold(i) complexes through post synthetic carbamate conjugation†

Sajal Sen,

^a Yue Li,

^b Vincent Lynch,

^a Kuppuswamy Arumugam,

^c Jonathan L. Sessler

*^a and Jonathan F. Arambula

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Texas at Austin, Austin, TX 78712-1224, USA
E-mail: sessler@cm.utexas.edu, jfarambula@cm.utexas.edu

^b College of Pharmacy, University of Texas at Austin, Austin, TX 78712-1224, USA

^c Department of Chemistry, Wright State University, 3640 Colonel Glenn Hwy, Dayton, Ohio, USA

Abstract

We report the synthesis of a novel hydroxyl-functionalised heteroleptic bis-NHC gold(I) complex that permits conjugation to various amines via carbamate bond formation. The resulting derivatives were studied in vitro using cell proliferation assays and fluorescent microscopic imaging of human cancer cell lines.

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Article information

DOI: https://doi.org/10.1039/C9CC05635A
Article type: Communication
Submitted: 21 Jul 2019
Accepted: 13 Aug 2019
First published: 14 Aug 2019

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Chem. Commun., 2019,55, 10627-10630

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Expanding the biological utility of bis-NHC gold(I) complexes through post synthetic carbamate conjugation

S. Sen, Y. Li, V. Lynch, K. Arumugam, J. L. Sessler and J. F. Arambula, Chem. Commun., 2019, 55, 10627 DOI: 10.1039/C9CC05635A

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Chemical Communications

Expanding the biological utility of bis-NHC gold(i) complexes through post synthetic carbamate conjugation†

Abstract

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Expanding the biological utility of bis-NHC gold(I) complexes through post synthetic carbamate conjugation

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