Issue 75, 2019

1,2-Aminohalogenation of arynes with amines and organohalides

Abstract

An unprecedented use of inexpensive organohalides as halogen electrophiles to trap the zwitterion intermediates generated from amines and arynes has been developed to access structurally diverse tertiary 2-haloanilines. Effective organohalides include carbon tetrachloride, hexachloroethane, N-chlorosuccinimide, carbon tetrabromide, fluorotribromomethane, N-bromosuccinimide, carbon tetraiodide, and N-iodosuccinimide.

Graphical abstract: 1,2-Aminohalogenation of arynes with amines and organohalides

Supplementary files

Article information

Article type
Communication
Submitted
17 Jul 2019
Accepted
26 Aug 2019
First published
27 Aug 2019

Chem. Commun., 2019,55, 11255-11258

1,2-Aminohalogenation of arynes with amines and organohalides

S. Li, L. Han and S. Tian, Chem. Commun., 2019, 55, 11255 DOI: 10.1039/C9CC05505C

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