Issue 70, 2019

Enzymatic kinetic resolution of chiral sulfoxides – an enantiocomplementary approach

Abstract

A new enzymatic assay for the preparation of chiral sulfoxides that is enantiocomplementary to the known (S)-enantiomer-reducing activity of methionine sulfoxide reductase A (MsrA) is described. To this end, we have utilized the enzyme DMSO reductase (DmsABC), recently discovered by us being highly upregulated in stationary phase E. coli bacteria.

Graphical abstract: Enzymatic kinetic resolution of chiral sulfoxides – an enantiocomplementary approach

Supplementary files

Article information

Article type
Communication
Submitted
16 Jul 2019
Accepted
08 Aug 2019
First published
08 Aug 2019

Chem. Commun., 2019,55, 10480-10483

Enzymatic kinetic resolution of chiral sulfoxides – an enantiocomplementary approach

V. Nosek and J. Míšek, Chem. Commun., 2019, 55, 10480 DOI: 10.1039/C9CC05470G

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