A dithiocarbamate-based H2O2-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy

Qingqing Pan; Boya Zhang; Xinyu Peng; Shiyu Wan; Kui Luo; Wenxia Gao; Yuji Pu; Bin He

doi:10.1039/C9CC05438C

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A dithiocarbamate-based H₂O₂-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy†

Qingqing Pan,^a Boya Zhang,^a Xinyu Peng,^a Shiyu Wan,^b Kui Luo,

^c Wenxia Gao,

^d Yuji Pu

*^a and Bin He^a

Author affiliations

* Corresponding authors

^a National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
E-mail: yjpu@scu.edu.cn

^b School of Chemical Engineering, Sichuan University, Chengdu 610065, China

^c Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China

^d College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325027, China

Abstract

Here, we report the rational design of a H₂O₂-responsive diethyldithiocarbamate (DTC)-based prodrug, which chelated Cu(II) to form Cu(DTC)₂ with a high anticancer activity in a tumor-microenvironment and induced oxidative stress amplification, showing superior antitumor toxicity to disulfiram.

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Article information

DOI: https://doi.org/10.1039/C9CC05438C
Article type: Communication
Submitted: 15 Jul 2019
Accepted: 25 Oct 2019
First published: 25 Oct 2019

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Chem. Commun., 2019,55, 13896-13899

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A dithiocarbamate-based H₂O₂-responsive prodrug for combinational chemotherapy and oxidative stress amplification therapy

Q. Pan, B. Zhang, X. Peng, S. Wan, K. Luo, W. Gao, Y. Pu and B. He, Chem. Commun., 2019, 55, 13896 DOI: 10.1039/C9CC05438C

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Chemical Communications