Issue 69, 2019

Facile synthesis of 1,2-thiobenzonitriles via Cu-catalyzed denitrogenative radical coupling reaction

Abstract

A Cu-catalyzed synthesis of 1,2-thiobenzonitriles via oxidative C–N cleavage of 3-aminoindazoles followed by radical coupling with thiols is developed. A diverse array of 1,2-thiobenzonitriles were obtained in good yields with wide substrate scope. Notably, this is the first example of denitrogenative radical coupling with 3-aminoindazoles.

Graphical abstract: Facile synthesis of 1,2-thiobenzonitriles via Cu-catalyzed denitrogenative radical coupling reaction

Supplementary files

Article information

Article type
Communication
Submitted
03 Jul 2019
Accepted
26 Jul 2019
First published
01 Aug 2019

Chem. Commun., 2019,55, 10265-10268

Facile synthesis of 1,2-thiobenzonitriles via Cu-catalyzed denitrogenative radical coupling reaction

Y. Zhou, Y. Wang, Y. Lou and Q. Song, Chem. Commun., 2019, 55, 10265 DOI: 10.1039/C9CC05099J

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