Issue 66, 2019
From the journal:

Chemical Communications

Molecular recognition of organophosphorus compounds in water and inhibition of their toxicity to acetylcholinesterase†

Wei-Er Liu,ab   Zhao Chen,b   Liu-Pan Yang, ORCID logo b   Ho Yu Au-Yeung ORCID logo *a  and  Wei Jiang ORCID logo *b  

* Corresponding authors

a Department of Chemistry, The University of Hong Kong, Hong Kong, China
E-mail: hoyuay@hku.hk

b Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen, China
E-mail: jiangw@sustech.edu.cn

Abstract

Molecular tubes with hydrogen bonding donors in their deep hydrophobic cavities are able to selectively bind organophosphorus compounds in water through hydrogen bonding and the hydrophobic effect. They can also be used as a fluorescent sensor for nerve agent simulants and as an inhibitor to reduce the toxicity of paraoxon to acetylcholinesterase.

Graphical abstract: Molecular recognition of organophosphorus compounds in water and inhibition of their toxicity to acetylcholinesterase

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Article information

DOI
https://doi.org/10.1039/C9CC04603H
Article type
Communication
Submitted
16 Jun 2019
Accepted
19 Jul 2019
First published
19 Jul 2019

Chem. Commun., 2019,55, 9797-9800

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Molecular recognition of organophosphorus compounds in water and inhibition of their toxicity to acetylcholinesterase

W. Liu, Z. Chen, L. Yang, H. Y. Au-Yeung and W. Jiang, Chem. Commun., 2019, 55, 9797 DOI: 10.1039/C9CC04603H

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