We herein demonstrate the UV resistance of glycol nucleic acid (GNA) dinucleotides. This resistance sustains the hypothesis of GNA as a nucleic acid prebiotic ancestor on early Earth, a time of intense solar UV light. Such photorobustness, due to the absence of intrastrand base stacking, could offer an opportunity for nanodevice development requiring challenging UV conditions.
S. Coantic-Castex, A. Martinez, D. Harakat, D. Guillaume and P. Clivio, Chem. Commun., 2019, 55, 12571 DOI: 10.1039/C9CC04355A
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