Issue 63, 2019
From the journal:

Chemical Communications

Mechanistic insights of Cu(ii)-mediated ortho-C–H amination of arenes by capturing fleeting intermediates and theoretical calculations†

Manoj Kumar,‡a   Shalini Verma,‡a   Anubhav Kumar,‡b   Pawan K. Mishra,a   Raghunath O. Ramabhadran, ORCID logo *b   Shibdas Banerjee ORCID logo *b  and  Akhilesh K. Verma ORCID logo *a  

* Corresponding authors

a Department of Chemistry, University of Delhi, Delhi 110007, India
E-mail: averma@acbr.du.ac.in

b Department of Chemistry, Indian Institute of Science Education and Research Tirupati, Tirupati 517507, India
E-mail: raghurama@iisertirupati.ac.in, shibdas@iisertirupati.ac.in

Abstract

The capture of reactive intermediates empowers chemists to conjecture the detail of a chemical transformation. Here we explore the mechanism of a C–H amination by intercepting short-lived intermediates in real time using online mass spectrometry. Computational study unravels the favorable pathway of the proposed dual mechanism of the reaction.

Graphical abstract: Mechanistic insights of Cu(ii)-mediated ortho-C–H amination of arenes by capturing fleeting intermediates and theoretical calculations

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Article information

DOI
https://doi.org/10.1039/C9CC04317A
Article type
Communication
Submitted
05 Jun 2019
Accepted
08 Jul 2019
First published
08 Jul 2019

Chem. Commun., 2019,55, 9359-9362

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Mechanistic insights of Cu(II)-mediated ortho-C–H amination of arenes by capturing fleeting intermediates and theoretical calculations

M. Kumar, S. Verma, A. Kumar, P. K. Mishra, R. O. Ramabhadran, S. Banerjee and A. K. Verma, Chem. Commun., 2019, 55, 9359 DOI: 10.1039/C9CC04317A

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