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Issue 67, 2019
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A neutral water-soluble mitochondria-targeting polymer

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Abstract

We report the first neutral and water-soluble polymer capable of strong mitochondrial targeting in vitro and in vivo, zwitterionic poly[2-(N-oxide-N,N-diethylamino)ethyl methacrylate] (OPDEA). OPDEA is quickly internalized via macropinocytosis by various cancer cells and transferred into the mitochondria, which slightly lowers the mitochondrial membrane potential as determined by the JC-1 assay.

Graphical abstract: A neutral water-soluble mitochondria-targeting polymer

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Supplementary files

Article information


Submitted
04 Jun 2019
Accepted
22 Jul 2019
First published
22 Jul 2019

Chem. Commun., 2019,55, 10015-10018
Article type
Communication

A neutral water-soluble mitochondria-targeting polymer

Y. Geng, Y. Zhong, Q. Zhou, S. Chen, Y. Piao, W. Yin, H. Lu and Y. Shen, Chem. Commun., 2019, 55, 10015
DOI: 10.1039/C9CC04291A

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