Enantiodiscrimination by matrix-assisted DOSY NMR

Abstract

High-resolution NMR is an essential technique for structure determination; however, stereochemistry assignment is still an obstacle. Several methods are known to overcome this limitation but usually at high costs or using derivatizations. Here we describe the use of different solvating agents to virtually discriminate the enantiomers of 15 analytes using ¹H and ¹⁹F-{¹H} DOSY NMR.