Iron-catalyzed oxidative functionalization of C(sp3)–H bonds under bromide-synergized mild conditions

Abstract

An efficient oxidation and functionalization of C–H bonds with an inorganic-ligand supported iron catalyst and hydrogen peroxide to prepare the corresponding ketones was achieved using the bromide ion as a promoter. Preliminary mechanistic investigations indicated that the bromide ion can bind to FeMo₆ to form a supramolecular species (FeMo₆·2Br), which can effectively catalyze the reaction.