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Issue 65, 2019
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Click and photo-release dual-functional nucleic acid nanostructures

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Abstract

We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.

Graphical abstract: Click and photo-release dual-functional nucleic acid nanostructures

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Article information


Submitted
16 May 2019
Accepted
23 Jul 2019
First published
29 Jul 2019

Chem. Commun., 2019,55, 9709-9712
Article type
Communication

Click and photo-release dual-functional nucleic acid nanostructures

V. A. Valsangkar, A. R. Chandrasekaran, L. Zhuo, S. Mao, G. W. Lee, M. Kizer, X. Wang, K. Halvorsen and J. Sheng, Chem. Commun., 2019, 55, 9709
DOI: 10.1039/C9CC03806J

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