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Issue 54, 2019
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Traceable in-cell synthesis and cytoplasm-to-nucleus translocation of a zinc Schiff base complex as a simple and economical anticancer strategy

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Abstract

We have proposed a facile and cheap cancer therapeutic strategy by in-cell synthesizing theranostic Zn Schiff base complexes with nuclear targeting and DNA damaging capability. The in-cell synthesis can be traced via a green-to-blue fluorescence shift, and the subsequent cytoplasm-to-nucleus translocation realizes cancer-specific therapy both in vitro and in vivo.

Graphical abstract: Traceable in-cell synthesis and cytoplasm-to-nucleus translocation of a zinc Schiff base complex as a simple and economical anticancer strategy

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Publication details

The article was received on 06 May 2019, accepted on 10 Jun 2019 and first published on 10 Jun 2019


Article type: Communication
DOI: 10.1039/C9CC03480C
Chem. Commun., 2019,55, 7852-7855

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    Traceable in-cell synthesis and cytoplasm-to-nucleus translocation of a zinc Schiff base complex as a simple and economical anticancer strategy

    Q. Cao, J. Yang, H. Zhang, L. Hao, G. Yang, L. Ji and Z. Mao, Chem. Commun., 2019, 55, 7852
    DOI: 10.1039/C9CC03480C

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