Jump to main content
Jump to site search

Issue 49, 2019
Previous Article Next Article

Lewis acid catalyzed annulation of spirocyclic donor–acceptor cyclopropanes with exo-heterocyclic olefins: access to highly functionalized bis-spirocyclopentane oxindole frameworks

Author affiliations

Abstract

Lewis acid catalyzed highly efficient [3+2] annulation of spirocyclic Donor–Acceptor cyclopropanes (DACs) with exo-heterocyclic olefins is reported to furnish various biologically relevant dispiro-2,3-dioxopyrrolidine[cyclopentane]oxindole and dispiropyrazolone[cyclopentane]oxindole frameworks. This report highlights the use of oxindole-activated spiro-DACs as potential synthons to access complex dispirocarbocyclic oxindoles via ring-enlargement of the former, with high yields and diastereoselectivity.

Graphical abstract: Lewis acid catalyzed annulation of spirocyclic donor–acceptor cyclopropanes with exo-heterocyclic olefins: access to highly functionalized bis-spirocyclopentane oxindole frameworks

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 May 2019, accepted on 24 May 2019 and first published on 24 May 2019


Article type: Communication
DOI: 10.1039/C9CC03393A
Chem. Commun., 2019,55, 7069-7072

  •   Request permissions

    Lewis acid catalyzed annulation of spirocyclic donor–acceptor cyclopropanes with exo-heterocyclic olefins: access to highly functionalized bis-spirocyclopentane oxindole frameworks

    K. Singh, S. Pramanik, T. A. Hamlin, B. Mondal, D. Das and J. Saha, Chem. Commun., 2019, 55, 7069
    DOI: 10.1039/C9CC03393A

Search articles by author

Spotlight

Advertisements