Issue 51, 2019

Versatile “on–off” biosensing of thrombin and miRNA based on Ag(i) ion-enhanced or Ag nanocluster-quenched electrochemiluminescence coupled with hybridization chain reaction amplification

Abstract

A novel biosensing platform based on the Ag(I) ion-enhanced or Ag nanocluster (NC)-quenched electrochemiluminescence (ECL) of CdSe quantum dots (QDs) was designed for versatile “on–off” assays of thrombin (TB) and miRNA, in which bipedal molecular machine (BMM)-triggered surface programmatic chain reaction (SPCR) coupled with mesoporous silica nanoparticle (MSN) multiple amplification is used to introduce plentiful QDs and Ag+ ions to significantly improve the ECL signal.

Graphical abstract: Versatile “on–off” biosensing of thrombin and miRNA based on Ag(i) ion-enhanced or Ag nanocluster-quenched electrochemiluminescence coupled with hybridization chain reaction amplification

Supplementary files

Article information

Article type
Communication
Submitted
26 Apr 2019
Accepted
28 May 2019
First published
06 Jun 2019

Chem. Commun., 2019,55, 7350-7353

Versatile “on–off” biosensing of thrombin and miRNA based on Ag(I) ion-enhanced or Ag nanocluster-quenched electrochemiluminescence coupled with hybridization chain reaction amplification

J. Ge, C. Li, Y. Zhao, X. Yu and G. Jie, Chem. Commun., 2019, 55, 7350 DOI: 10.1039/C9CC03235E

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