An ultrasensitive ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the quantitative measurement of pH values in the endoplasmic reticulum (ER)

Baoli Dong; Wenhui Song; Yaru Lu; Xiuqi Kong; Abdul Hadi Mehmood; Weiying Lin

doi:10.1039/C9CC03114F

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An ultrasensitive ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the quantitative measurement of pH values in the endoplasmic reticulum (ER)†

Baoli Dong,

^a Wenhui Song,^a Yaru Lu,^a Xiuqi Kong,

^a Abdul Hadi Mehmood^a and Weiying Lin

*^a

Author affiliations

* Corresponding authors

^a Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Jinan, Shandong 250022, People's Republic of China
E-mail: weiyinglin2013@163.com

Abstract

Herein, we present a dual-site ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the detection of pH in the ER. The probe showed a highly sensitive response to pH in the range of 5.0–7.2, and could be applied for the quantitative measurement of the pH values in the ER during ER stress and dexamethanose-induced stimulation.

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Article information

DOI: https://doi.org/10.1039/C9CC03114F
Article type: Communication
Submitted: 22 Apr 2019
Accepted: 13 Aug 2019
First published: 15 Aug 2019

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Chem. Commun., 2019,55, 10776-10779

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An ultrasensitive ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the quantitative measurement of pH values in the endoplasmic reticulum (ER)

B. Dong, W. Song, Y. Lu, X. Kong, A. H. Mehmood and W. Lin, Chem. Commun., 2019, 55, 10776 DOI: 10.1039/C9CC03114F

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Chemical Communications

An ultrasensitive ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the quantitative measurement of pH values in the endoplasmic reticulum (ER)†

Abstract

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An ultrasensitive ratiometric fluorescent probe based on the ICT-PET-FRET mechanism for the quantitative measurement of pH values in the endoplasmic reticulum (ER)

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