A bicyclization reaction with two molecular allenyl ketones and isocyanides: synthesis of a lactone-containing azaspirocycle derivative

Abstract

A novel bicyclization reaction of two molecular allenyl ketones and isocyanides has been disclosed. This strategy allows for the construction of structurally complex spirocyclic lactam–lactone systems in an efficient manner. This protocol also demonstrates other advantages such as high synthetic efficiency, atom economy, and broad substrate scope under mild conditions.