Co(ii)/Cu(ii)-cocatalyzed oxidative C–H/N–H functionalization of benzamides with ketones: a facile route to isoindolin-1-ones

Abstract

A cobalt and copper catalyzed reaction protocol has been developed to achieve the oxidative C–H/N–H annulation of benzamides containing an 8-aminoquinoline moiety as the directing group with ketones. Structurally diverse isoindolin-1-ones were furnished by the reaction of various substituent benzamides with ketones.