Issue 47, 2019
From the journal:

Chemical Communications

A Golgi-targeted off–on fluorescent probe for real-time monitoring of pH changes in vivo†

Li Fan, ORCID logo ‡*a   Xiaodong Wang,‡a   Jinyin Ge,a   Feng Li, ORCID logo *b   Caihong Zhang,a   Bo Lin,a   Shaomin Shuang ORCID logo a  and  Chuan Dong ORCID logo *a  

* Corresponding authors

a Institute of Environmental Science, College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, P. R. China
E-mail: fanli128@sxu.edu.cn, dc@sxu.edu.cn

b Department of Chemistry, Centre for Biotechnology, Brock University, St. Catharines, Ontario, Canada
E-mail: fli@brocku.ca

Abstract

We present the first Golgi-targeted small-molecular pH-sensitive fluorescent probe RSG, which allows an off–on fluorescence response to Golgi acidification with high sensitivity and specificity. RSG has been successfully used for real-time monitoring of Golgi pH changes induced by drug treatment at the cellular level, as well as by the LPS-mediated inflammation in vivo.

Graphical abstract: A Golgi-targeted off–on fluorescent probe for real-time monitoring of pH changes in vivo

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Article information

DOI
https://doi.org/10.1039/C9CC02511A
Article type
Communication
Submitted
01 Apr 2019
Accepted
10 May 2019
First published
10 May 2019

Chem. Commun., 2019,55, 6685-6688

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A Golgi-targeted off–on fluorescent probe for real-time monitoring of pH changes in vivo

L. Fan, X. Wang, J. Ge, F. Li, C. Zhang, B. Lin, S. Shuang and C. Dong, Chem. Commun., 2019, 55, 6685 DOI: 10.1039/C9CC02511A

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