In situ visualization of peroxisomal peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride using a new two-photon fluorescent probe

Yongqing Zhou; Ping Li; Nannan Fan; Xin Wang; Xiaoning Liu; Lijie Wu; Wen Zhang; Wei Zhang; Changle Ma; Bo Tang

doi:10.1039/C9CC02483B

In situ visualization of peroxisomal peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride using a new two-photon fluorescent probe†

Yongqing Zhou,‡^a Ping Li,‡^a Nannan Fan,^a Xin Wang,^a Xiaoning Liu,^a Lijie Wu,^a Wen Zhang,^a Wei Zhang,^a Changle Ma*^b and Bo Tang

*^a

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* Corresponding authors

^a College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Shandong Normal University, Jinan 250014, People's Republic of China
E-mail: tangb@sdnu.edu.cn, changlema@yahoo.com

^b College of Life Sciences, Shandong Normal University, Jinan 250014, P. R. China

Abstract

We developed a new two-photon fluorescent probe (PX-1) with high selectivity and sensitivity for detecting peroxisomal peroxynitrite. PX-1 was successfully applied to in situ imaging of peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride.

Chemical Communications

In situ visualization of peroxisomal peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride using a new two-photon fluorescent probe†

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In situ visualization of peroxisomal peroxynitrite in the livers of mice with acute liver injury induced by carbon tetrachloride using a new two-photon fluorescent probe

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