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Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)–Pd complexes

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Abstract

The enantioselective conjugate addition reaction of an α,α-dithioacetonitrile with nitroalkenes was catalysed by chiral bis(imidazoline)–palladium pincer-type complexes. The reaction was applicable to various nitroalkenes to afford products in good yield with high enantioselectivity. The obtained products can be converted to γ-lactam and biologically active rolipram.

Graphical abstract: Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)–Pd complexes

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Publication details

The article was received on 29 Mar 2019, accepted on 15 Apr 2019 and first published on 15 Apr 2019


Article type: Communication
DOI: 10.1039/C9CC02443C
Citation: Chem. Commun., 2019, Advance Article

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    Enantioselective conjugate addition of an α,α-dithioacetonitrile with nitroalkenes using chiral bis(imidazoline)–Pd complexes

    S. Nakamura, A. Tokunaga, H. Saito and M. Kondo, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC02443C

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