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Promotion of Appel-Type Reactions by N-Heterocyclic Carbenes

Abstract

N-Heterocyclic carbenes (NHCs) have been used extensively as a versatile class of catalysts and ligands in organocatalytic and organometallic chemistry. However, there are only a small number of synthetic applications where they act as reagents. Here we demonstrate that NHCs can be used as stoichiometric redox reagents for Appel-type halogenation reactions of alcohols. This new reactivity reveals a fresh and interesting aspect and enriches chemistry of NHCs in an underexplored area. The potential of performing this chemical transformation at catalytic level using an NHC-oxide derivative is also investigated.

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Publication details

The article was received on 16 Mar 2019, accepted on 11 Jun 2019 and first published on 12 Jun 2019


Article type: Communication
DOI: 10.1039/C9CC02132A
Chem. Commun., 2019, Accepted Manuscript

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    Promotion of Appel-Type Reactions by N-Heterocyclic Carbenes

    M. A. Hussein and T. V. Nguyen, Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9CC02132A

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