Issue 43, 2019
From the journal:

Chemical Communications

A spermine-conjugated lipophilic Pt(iv) prodrug designed to eliminate cancer stem cells in ovarian cancer†

Morgan Stilgenbauer,a   Amarasooriya M. D. S. Jayawardhana,a   Payel Datta,a   Zhizhou Yue,a   Michael Gray,a   Frederick Nielsen,a   David J. Bowers,a   Haihua Xiao*b  and  Yao-Rong Zheng ORCID logo *a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Kent State University, 224 Williams Hall, Kent, Ohio 44242, USA
E-mail: yzheng7@kent.edu

b Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
E-mail: hhxiao@iccac.ac.cn

Abstract

We developed a spermine-conjugated lipophilic Pt(IV) prodrug that is able to reduce the cancer stem cell population in ovarian cancer. The therapeutic effect is attributed to the hydrophobic tail and cationic spermine head group, the combination of which allows the Pt(IV) prodrug to localize in mitochondria and induce corresponding damage.

Graphical abstract: A spermine-conjugated lipophilic Pt(iv) prodrug designed to eliminate cancer stem cells in ovarian cancer

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Article information

DOI
https://doi.org/10.1039/C9CC02081K
Article type
Communication
Submitted
14 Mar 2019
Accepted
26 Apr 2019
First published
01 May 2019

Chem. Commun., 2019,55, 6106-6109

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A spermine-conjugated lipophilic Pt(IV) prodrug designed to eliminate cancer stem cells in ovarian cancer

M. Stilgenbauer, A. M. D. S. Jayawardhana, P. Datta, Z. Yue, M. Gray, F. Nielsen, D. J. Bowers, H. Xiao and Y. Zheng, Chem. Commun., 2019, 55, 6106 DOI: 10.1039/C9CC02081K

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