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Issue 39, 2019
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A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

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Abstract

A supramolecular synthon approach was exploited to design amorphous solid dispersions (ASDs) of drugs containing an amino aromatic nitrogen moiety and a polyacrylic acid polymer. The interaction between a drug and polymer was confirmed by differential scanning calorimetry, spectroscopy (IR and 15N NMR), and X-ray crystallography. The interaction decreased the molecular mobility, conferred exceptional physical stability and enhanced the drug dissolution.

Graphical abstract: A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

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Publication details

The article was received on 13 Mar 2019, accepted on 29 Mar 2019 and first published on 30 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC02021G
Chem. Commun., 2019,55, 5551-5554

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    A supramolecular synthon approach to design amorphous solid dispersions with exceptional physical stability

    N. K. Duggirala, J. Li, N. S. K. Kumar, T. Gopinath and R. Suryanarayanan, Chem. Commun., 2019, 55, 5551
    DOI: 10.1039/C9CC02021G

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