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Abstract | Cited by

We report the synthesis and use of sydnone-based profluorophores as tools for imaging applications. These new probes display exquisite reactivity towards strain promoted cycloaddition reactions with cycloalkynes allowing fast, efficient and selective labeling in biological media. Styryl-pyridinium sydnone probes were found particularly interesting for click reactions to proceed selectively inside cells.

Graphical abstract: Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging

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