Issue 26, 2019

An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms

Abstract

Multidrug resistance mediated by the overexpression of ABC transporters is a major challenge in cancer chemotherapy. Here, we report the synthesis of an organoruthenium complex, RuF, that was designed to surmount multidrug resistance by combining ABCG2 inhibition and cancer cell cytotoxicity, yielding synergistic efficacy.

Graphical abstract: An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms

Supplementary files

Article information

Article type
Communication
Submitted
31 Jan 2019
Accepted
06 Mar 2019
First published
06 Mar 2019

Chem. Commun., 2019,55, 3833-3836

An organoruthenium complex overcomes ABCG2-mediated multidrug resistance via multiple mechanisms

L. Zeng, J. Li, C. Zhang, Y. Zhang, W. Zhang, J. Huang, C. R. Ashby, Z. Chen and H. Chao, Chem. Commun., 2019, 55, 3833 DOI: 10.1039/C9CC00882A

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