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Versatile fluorescence detection of microRNA based on novel DNA hydrogel-amplified signal probes coupled with DNA walker amplification

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Abstract

A novel DNA hydrogel-amplified versatile fluorescence platform combined with hybridization chain reaction (HCR) and DNA walking multiple amplification was developed for ultrasensitive detection of miRNA. The DNA hydrogel was loaded with large amounts of SYBR Green (SG) I dyes or CdTe quantum dots (QDs) to assemble versatile signal probes.

Graphical abstract: Versatile fluorescence detection of microRNA based on novel DNA hydrogel-amplified signal probes coupled with DNA walker amplification

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Publication details

The article was received on 22 Jan 2019, accepted on 06 Mar 2019 and first published on 14 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC00565J
Citation: Chem. Commun., 2019, Advance Article

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    Versatile fluorescence detection of microRNA based on novel DNA hydrogel-amplified signal probes coupled with DNA walker amplification

    C. Li, H. Li, J. Ge and G. Jie, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C9CC00565J

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