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Issue 26, 2019
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Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

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Abstract

We report the synthesis of poly(2-ethyl-2-oxazoline)-based (PEtOx) nanoobjects by polymerization-induced self-assembly (PISA). First, well-defined PEtOx macromolecular chain transfer agents were synthesized by cationic ring-opening polymerization and click chemistry. The photoinitiated PISA of 2-hydroxypropyl methacrylate mediated by these PEtOx produced nanoobjects spanning the full range of core–shell morphologies. The nanoparticles exhibited high biocompatibility and stealth properties in vitro or in vivo, as well as thermoresponsive behavior.

Graphical abstract: Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

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Supplementary files

Article information


Submitted
16 Jan 2019
Accepted
21 Feb 2019
First published
25 Feb 2019

This article is Open Access

Chem. Commun., 2019,55, 3741-3744
Article type
Communication

Straightforward access to biocompatible poly(2-oxazoline)-coated nanomaterials by polymerization-induced self-assembly

D. Le, F. Wagner, M. Takamiya, I. Hsiao, G. Gil Alvaradejo, U. Strähle, C. Weiss and G. Delaittre, Chem. Commun., 2019, 55, 3741
DOI: 10.1039/C9CC00407F

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