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Issue 29, 2019
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Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

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Abstract

The tert-butanol (TBA)–water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).

Graphical abstract: Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

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Article information


Submitted
16 Jan 2019
Accepted
18 Mar 2019
First published
19 Mar 2019

Chem. Commun., 2019,55, 4262-4265
Article type
Communication

Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

A. G. Ogienko, A. S. Stoporev, A. A. Ogienko, M. S. Mel’gunov, T. P. Adamova, A. S. Yunoshev, A. Yu. Manakov and E. V. Boldyreva, Chem. Commun., 2019, 55, 4262
DOI: 10.1039/C9CC00397E

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