Jump to main content
Jump to site search

Issue 29, 2019
Previous Article Next Article

Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

Author affiliations

Abstract

The tert-butanol (TBA)–water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).

Graphical abstract: Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 Jan 2019, accepted on 18 Mar 2019 and first published on 19 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC00397E
Chem. Commun., 2019,55, 4262-4265

  •   Request permissions

    Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

    A. G. Ogienko, A. S. Stoporev, A. A. Ogienko, M. S. Mel’gunov, T. P. Adamova, A. S. Yunoshev, A. Yu. Manakov and E. V. Boldyreva, Chem. Commun., 2019, 55, 4262
    DOI: 10.1039/C9CC00397E

Search articles by author

Spotlight

Advertisements