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Issue 60, 2019
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A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

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Abstract

We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.

Graphical abstract: A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

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Publication details

The article was received on 15 Jan 2019, accepted on 13 Jun 2019 and first published on 13 Jun 2019


Article type: Communication
DOI: 10.1039/C9CC00375D
Chem. Commun., 2019,55, 8860-8863

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    A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence

    R. T. Kadakia, D. Xie, D. Martinez, M. Yu and E. L. Que, Chem. Commun., 2019, 55, 8860
    DOI: 10.1039/C9CC00375D

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