A dual-responsive probe for detecting cellular hypoxia using 19F magnetic resonance and fluorescence†
We report the first dual-responsive 19F MRI and fluorescence imaging probe for cellular hypoxia. The Cu2+-based probe exhibits no 19F MR signal and reduced fluorescence signal due to paramagnetic quenching; however, the probe turns-on in both modes following reduction to Cu+. This bimodal agent can differentiate hypoxic and normoxic cells in both modalities.
- This article is part of the themed collection: 2019 Emerging Investigators