Issue 14, 2019
From the journal:

Chemical Communications

A self-assembled peptide nucleic acid–microRNA nanocomplex for dual modulation of cancer-related microRNAs†

Xingxing Wang,a   Xiao Xiao,a   Bingsen Zhang,a   Jinbo Li ORCID logo *a  and  Yan Zhang ORCID logo *a  

* Corresponding authors

a State Key Laboratory of Analytical Chemistry for Life Sciences, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China
E-mail: jinboli@nju.edu.cn, njuzy@nju.edu.cn

Abstract

Here, we report a new strategy for the construction of a peptide nucleic acid–microRNA nanocomplex with dual function to simultaneously suppress oncogenic microRNAs and upregulate tumor-suppressive microRNAs in target cancer cells.

Graphical abstract: A self-assembled peptide nucleic acid–microRNA nanocomplex for dual modulation of cancer-related microRNAs

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Article information

DOI
https://doi.org/10.1039/C9CC00002J
Article type
Communication
Submitted
01 Jan 2019
Accepted
22 Jan 2019
First published
23 Jan 2019

Chem. Commun., 2019,55, 2106-2109

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A self-assembled peptide nucleic acid–microRNA nanocomplex for dual modulation of cancer-related microRNAs

X. Wang, X. Xiao, B. Zhang, J. Li and Y. Zhang, Chem. Commun., 2019, 55, 2106 DOI: 10.1039/C9CC00002J

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