Issue 31, 2019

DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA

Abstract

We identified 29 G-quadruplex binding proteins by affinity purification and quantitative LC-MS/MS. We demonstrated that the DEAD-box RNA helicases Dbp2, Ded1 and Mss116 preferentially bind to G-quadruplex nucleic acids in vitro and destabilize RNA quadruplexes, suggesting new potential roles for these helicases in disruption of quadruplex structures in RNA.

Graphical abstract: DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA

Supplementary files

Article information

Article type
Communication
Submitted
20 Dec 2018
Accepted
14 Feb 2019
First published
11 Mar 2019
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2019,55, 4467-4470

DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA

J. Gao, A. K. Byrd, B. L. Zybailov, J. C. Marecki, M. J. Guderyon, A. D. Edwards, S. Chib, K. L. West, Z. J. Waldrip, S. G. Mackintosh, Z. Gao, A. A. Putnam, E. Jankowsky and K. D. Raney, Chem. Commun., 2019, 55, 4467 DOI: 10.1039/C8CC10091H

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