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Issue 18, 2019
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Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures

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Abstract

Here we investigate and reveal the effect of bulge position and bulge identity on G-quadruplexes using label-free spectroscopic techniques. Notably, we report significant differences in the spectroscopic features of bulged DNA and RNA G-quadruplexes, and demonstrate that intrinsic fluorescence can be generally used to detect the formation of canonical and non-canonical G-quadruplexes.

Graphical abstract: Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures

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Publication details

The article was received on 15 Dec 2018, accepted on 28 Jan 2019 and first published on 29 Jan 2019


Article type: Communication
DOI: 10.1039/C8CC09929D
Citation: Chem. Commun., 2019,55, 2616-2619

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    Spectroscopic analysis reveals the effect of a single nucleotide bulge on G-quadruplex structures

    C. Chan, M. I. Umar and C. K. Kwok, Chem. Commun., 2019, 55, 2616
    DOI: 10.1039/C8CC09929D

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