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Transition-metal-free α-arylation of nitroketones with diaryliodonium salts for the synthesis of tertiary α-aryl, α-nitro ketones

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Abstract

Transition-metal-free α-arylation of α-nitroketones with diaryliodonium salts has been realized for the first time. As an application of this methodology, a concise synthesis of the clinical drug tiletamine was also achieved via a three-step procedure from 2-nitrocyclohexanone without the isolation of intermediates.

Graphical abstract: Transition-metal-free α-arylation of nitroketones with diaryliodonium salts for the synthesis of tertiary α-aryl, α-nitro ketones

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Publication details

The article was received on 09 Nov 2018, accepted on 27 Nov 2018 and first published on 28 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08920E
Citation: Chem. Commun., 2019, Advance Article
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    Transition-metal-free α-arylation of nitroketones with diaryliodonium salts for the synthesis of tertiary α-aryl, α-nitro ketones

    Y. An, X. Zhang, Z. Li, W. Xiong, R. Yu and F. Zhang, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08920E

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