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Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation

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Abstract

Here, we report the first synthesis of quasi-stable trimer models of full-length Aβ40 with a toxic conformation using a 1,3,5-phenyltris-L-alanyl linker at position 34, 36, or 38. The only trimer to exhibit weak neurotoxicity against SH-SY5Y cells was the one which was linked at position 38. This suggests that such a propeller-type trimer model is not prone to forming oligomers with potent neurotoxicity, which is in contrast with its corresponding dimer model.

Graphical abstract: Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation

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Publication details

The article was received on 28 Oct 2018, accepted on 30 Nov 2018 and first published on 30 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC08618D
Citation: Chem. Commun., 2019, Advance Article
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    Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation

    Y. Irie, M. Hanaki, K. Murakami, T. Imamoto, T. Furuta, T. Kawabata, T. Kawase, K. Hirose, Y. Monobe, K. Akagi, R. C. Yanagita and K. Irie, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08618D

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