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A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA

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Abstract

Herein, we identify supramolecular self-associating amphiphiles (SSAs) as a novel class of antibacterials with activity towards methicillin-resistant Staphylococcus aureus. Structure–activity relationships have been identified in the solid, solution and gas phases. Finally, we show that when supplied in combination, SSAs exhibit increased antibacterial efficacy against these clinically relevant microbes.

Graphical abstract: A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA

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Publication details

The article was received on 23 Oct 2018, accepted on 05 Nov 2018 and first published on 04 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC08485H
Citation: Chem. Commun., 2019, Advance Article
  • Open access: Creative Commons BY license
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    A symbiotic supramolecular approach to the design of novel amphiphiles with antibacterial properties against MSRA

    S. N. Tyuleva, N. Allen, L. J. White, A. Pépés, H. J. Shepherd, P. J. Saines, R. J. Ellaby, D. P. Mulvihill and J. R. Hiscock, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC08485H

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