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A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude

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Abstract

We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular ligands open up an opportunity to modulate functions of 14-3-3 with these effectors.

Graphical abstract: A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude

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Publication details

The article was received on 04 Oct 2018, accepted on 26 Nov 2018 and first published on 26 Nov 2018


Article type: Communication
DOI: 10.1039/C8CC07946C
Citation: Chem. Commun., 2019, Advance Article
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    A new class of supramolecular ligands stabilizes 14-3-3 protein–protein interactions by up to two orders of magnitude

    A. Gigante, J.-N. Grad, J. Briels, M. Bartel, D. Hoffmann, C. Ottmann and C. Schmuck, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC07946C

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