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Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations

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Abstract

We demonstrate the coupling of liquid extraction surface analysis (LESA) to structures for lossless ion manipulations in conjunction with serpentine ultralong path with extending routing (SLIM SUPER) ion mobility-mass spectrometry (IM-MS) for the unambiguous annotation of important isomeric glycoforms in carbon-fixing communities.

Graphical abstract: Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations

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Publication details

The article was received on 14 Sep 2018, accepted on 29 Nov 2018 and first published on 07 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC07482H
Citation: Chem. Commun., 2019, Advance Article
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    Towards resolving the spatial metabolome with unambiguous molecular annotations in complex biological systems by coupling mass spectrometry imaging with structures for lossless ion manipulations

    G. Nagy, D. Veličković, R. K. Chu, A. A. Carrell, D. J. Weston, Y. M. Ibrahim, C. R. Anderton and R. D. Smith, Chem. Commun., 2019, Advance Article , DOI: 10.1039/C8CC07482H

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