Issue 5, 2019

Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity

Abstract

Mincle, expressed in activated phagocytes, recognizes the lipid ligand to activate the innate immune system. We have synthesized glycerol derivatives possessing simple alkyl chains or aromatic rings and elucidated their structure–activity relationships using a Mincle-mediated signaling assay. The activity depends on the length of the simple acyl chains of the glycerol derivatives.

Graphical abstract: Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
09 Sep 2018
Accepted
08 Dec 2018
First published
10 Dec 2018

Chem. Commun., 2019,55, 711-714

Synthesis of glycerolipids containing simple linear acyl chains or aromatic rings and evaluation of their Mincle signaling activity

T. Matsumaru, R. Ikeno, Y. Shuchi, T. Iwamatsu, T. Tadokoro, S. Yamasaki, Y. Fujimoto, A. Furukawa and K. Maenaka, Chem. Commun., 2019, 55, 711 DOI: 10.1039/C8CC07322H

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